Isolation and Functioning Investigation of Salvia hispanica Seed Mucilage as A Potential Sustained Release Carrier for Water Soluble Drug

Abstract: Background: Natural biopolymers or hydrogels that are biodegradable and safe from biological point of view along with their capability to retain active principle within network thus prolonging the release. The present work was undertaken explore potential mucilage mature seeds Chia (Salvia hispanica) sustain release water-soluble drugs. Losartan potassium used as a model prepare gelispheres. Materials Methods: isolated physicochemical properties like viscosity, phytoconstituent, FTIR, hydration index were studied. Gelispheres loaded drug Potassium (LP) prepared using sodium alginate, pectin CSM in various ratios by polyelectrolyte complexation (Ionic Gelation) method. Micrometric properties, surface contour analysis, ex vivo mucoadhesion study, vitro compatibility, XRD, stability statistical analysis carried out on Results: possesses immense viscosity modification capacity, consistency, excellent mucoadhesive nature can be explored for developing principal delivery devices. Conclusion: developed gelispheres exhibited good which enabled sustaining prolonged duration advocating use design twice daily losartan system management hypertension. Keywords: seed mucilage, Gelisphere, Mucoadhesion, potassium, Ionic gelation.